Immunogenicity and infectivity of mature and immature plasmodium gallinaceum sporozoites
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Viability and Infectivity of Cryopreserved Plasmodium Vivax Sporozoites.
Plasmodium vivax presents a great challenge to malaria control because of the ability of its dormant form in the liver, the hypnozoite, to cause relapse in otherwise fully recovered patient. Research efforts to better understand P. vivax hypnozoite biology have been hampered by the limited availability of its sporozoite form responsible for liver infection. Thus, the ability to cryopreserve and...
متن کاملInfectivity and neutralization of Cryptosporidium parvum sporozoites.
Cryptosporidiosis, a diarrheal disease of calves and humans caused by the coccidian parasite Cryptosporidium parvum, is terminated in hosts with normal immune systems. To assess the mechanisms of immunity in cryptosporidiosis, it is necessary to isolate and quantitate sporozoites, the infective stage of Cryptosporidium spp. Here we report the (i) separation of infective C. parvum oocysts from c...
متن کاملTRAP Is Necessary for Gliding Motility and Infectivity of Plasmodium Sporozoites
Many protozoans of the phylum Apicomplexa are invasive parasites that exhibit a substrate-dependent gliding motility. Plasmodium (malaria) sporozoites, the stage of the parasite that invades the salivary glands of the mosquito vector and the liver of the vertebrate host, express a surface protein called thrombospondin-related anonymous protein (TRAP) that has homologs in other Apicomplexa. By g...
متن کاملInhibitor of Cysteine Proteases Is Critical for Motility and Infectivity of Plasmodium Sporozoites
UNLABELLED Malaria is transmitted when motile sporozoites are injected into the dermis by an infected female Anopheles mosquito. Inside the mosquito vector, sporozoites egress from midgut-associated oocysts and eventually penetrate the acinar cells of salivary glands. Parasite-encoded factors with exclusive vital roles in the insect vector can be studied by classical reverse genetics. Here, we ...
متن کاملThe Immunization of Fowls against Mosquito-borne Plasmodium Gallinaceum by Injections of Serum and of Inactivated Homologous Sporozoites
This paper reports attempts to immunize domestic fowls against mosquito-borne infections of Plasmodium gallinaceum by means of (a) vaccination with inactivated homologous sporozoites; (b) injections of sera, both normal sheep serum, and serum from fowls chronically infected with the homologous Plasmodium, (c) combinations of both sporozoite vaccine and serum. It was possible to reduce the norma...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 1986
ISSN: 0074-0276
DOI: 10.1590/s0074-02761986000600019